As reports Sky News with the reference to the official site of British imperial college (Imperial College London), British scientists work at the creation of new medicine for obesity on the basis of the hormone, which causes in man a feeling of satiety. The first tests showed that the specific doses of pancreatic polypeptide - the "hormone of satiety" - can reduce a quantity of consumed food to 15-20%. Mice, on which was experienced the preparation, in the week lost 15% of its weight. It is assumed that initially the medicine will be introduced into the organism with the aid of the injections and it can be obtained after only 5-8 years, but in the long-term outlook scientists hope to develop the preparation, which can be absorbed the mucous cavity of mouth.
In that case it will be possible to place this medicine into chewing gum or drops for the nose. In one England alone in yr from the consequences of obesity it dies to 30 thousand people, in essence from the diseases of heart and diabetes. (Reviewed site: Viagra without prescription)
Medicines for the treatment of obesity, accessible at the given moment, have a large quantity of side effects and they can be dangerous for the health. To the study of the action of pancreatic polypeptide on the human organism company Wellcome Trust isolated Grant in the size 2,2 mln. it was pounds sterling. (http://www.acyclovirwithoutprescription.org/)
Monday, January 14, 2008
To lull to sleep insomnia
The study of people, which unexpectedly fill up during the day, led to the discovery of the new class of preparations from insomnia. They act on the same hormone, which answers for the state of satiety and intoxication. Swiss biochemists invented new approach to the treatment of insomnia. The treatment of ailment is connected with the blocking of the action of the neurohormone of orexin (hypo-cretin). It acts on the hypothalamus and (in the number of other) it answers for the emotions, the sexual and food activity, and also for the processes of intoxication and sleepiness.
The substance, which blocks orexin, is called Acts -078573. The researchers headed by Francois zhenk from the biotechnical company Actelion Pharmaceuticals explained after a number of the experiments above the rats, the dogs and the people that it decreases the anxiety of patients, and also noticeably is decreased the quantity of time, necessary for the falling asleep of all experimental. The level of orexin directly influences the sleep of man. For example, in patients with the disturbance of sleep, called narcolepsy, the level of orexin is extremely low. The ailment indicated is manifested in the form of sharp day sleepiness, which is so heavy that people fill up, even in spite of extreme unwillingness or inappropriate situation. Such fallings asleep can be repeated several times in the day and last from the pair of seconds to several minutes.
Furthermore, narcolepsy is expressed by the assaults of katapleksii - the complete weakening of skeletal muscles, with which remains only the capability for involuntary respiration. Provoke this assault can practically any strong stimulus - excitation, fear, anger, confusion, sexual relations, but especially frequently - laughter. As already stated Zhenk, nothing similar with the people, which will assume its medicine for insomnia, it will not occur. Among those tested preparation not it was noted neither katapleksii nor hallucinations - of one additional sign of narcolepsy. Other researchers already noted that the results of the tests, carry ouied Zhenkom, were preliminary. Moreover, preparation must be still checked in order to define, so it is safe and effective, as its developers stated - Buy soma.
Sage Nishino, that studies the phenomenon of sleep at the Stanford university, stated that all data were based at the single method of preparation with group of 42 healthy men without any disorders of sleep. However, the majorities of those suffering from insomnia experience chronic problems with the sleep and they need more prolonged therapy. According to Zhenka, criticism it perceived and already began prolonged action research of medicine on the organisms of those suffering for insomnia. Furthermore, Nishino he stated that the majority of the patients, in whom was diagnosed narcolepsy, do not note the loss of tone muscle earlier than 6-12 months after the beginning of the assaults of day sleepiness. This means that the bright clinical picture of disease will be accessible only with sufficient- after all the prolonged hormonal "starvation". At the same time, as is known, orexin participates in the processes of the regulation of appetite. Thus, the preparation, the locking action of this neurohormone, can have side-effect by weight of patient. "if we examine these and other functions of orexin, we, possibly, will reveal other methods of its application", noted Nishino. However, such methods of using a similar medicine already exist. Buy valium
Recently scientists from the institute of Howard Flory (Melbourne) also created the substance, the locking action of orexin. However, in this case preparation is intended to patients, who suffer from alcoholism. Researchers under Lawrence's management by Andrews conducted a number of the experiments above the laboratory rats, in course of which they explained that the rodents, which passed the purification of organism and assumed the blocker of hormone, not only forewent the method of alcohol, but also they did not return to this habit again, in spite of all created conditions. Accordingly, blocking orexin potentially can have a positive effect not only on people with the disorders of sleep, but also on the patients, who suffer from various forms of dependences. However, to become acquainted with the results of investigating Francois zhenk is possible in the last release of periodical Nature Medicine. But with the "alcoholic" action of neurohormone - also into Nature, only in July 2006. Valium without prescription
The substance, which blocks orexin, is called Acts -078573. The researchers headed by Francois zhenk from the biotechnical company Actelion Pharmaceuticals explained after a number of the experiments above the rats, the dogs and the people that it decreases the anxiety of patients, and also noticeably is decreased the quantity of time, necessary for the falling asleep of all experimental. The level of orexin directly influences the sleep of man. For example, in patients with the disturbance of sleep, called narcolepsy, the level of orexin is extremely low. The ailment indicated is manifested in the form of sharp day sleepiness, which is so heavy that people fill up, even in spite of extreme unwillingness or inappropriate situation. Such fallings asleep can be repeated several times in the day and last from the pair of seconds to several minutes.
Furthermore, narcolepsy is expressed by the assaults of katapleksii - the complete weakening of skeletal muscles, with which remains only the capability for involuntary respiration. Provoke this assault can practically any strong stimulus - excitation, fear, anger, confusion, sexual relations, but especially frequently - laughter. As already stated Zhenk, nothing similar with the people, which will assume its medicine for insomnia, it will not occur. Among those tested preparation not it was noted neither katapleksii nor hallucinations - of one additional sign of narcolepsy. Other researchers already noted that the results of the tests, carry ouied Zhenkom, were preliminary. Moreover, preparation must be still checked in order to define, so it is safe and effective, as its developers stated - Buy soma.
Sage Nishino, that studies the phenomenon of sleep at the Stanford university, stated that all data were based at the single method of preparation with group of 42 healthy men without any disorders of sleep. However, the majorities of those suffering from insomnia experience chronic problems with the sleep and they need more prolonged therapy. According to Zhenka, criticism it perceived and already began prolonged action research of medicine on the organisms of those suffering for insomnia. Furthermore, Nishino he stated that the majority of the patients, in whom was diagnosed narcolepsy, do not note the loss of tone muscle earlier than 6-12 months after the beginning of the assaults of day sleepiness. This means that the bright clinical picture of disease will be accessible only with sufficient- after all the prolonged hormonal "starvation". At the same time, as is known, orexin participates in the processes of the regulation of appetite. Thus, the preparation, the locking action of this neurohormone, can have side-effect by weight of patient. "if we examine these and other functions of orexin, we, possibly, will reveal other methods of its application", noted Nishino. However, such methods of using a similar medicine already exist. Buy valium
Recently scientists from the institute of Howard Flory (Melbourne) also created the substance, the locking action of orexin. However, in this case preparation is intended to patients, who suffer from alcoholism. Researchers under Lawrence's management by Andrews conducted a number of the experiments above the laboratory rats, in course of which they explained that the rodents, which passed the purification of organism and assumed the blocker of hormone, not only forewent the method of alcohol, but also they did not return to this habit again, in spite of all created conditions. Accordingly, blocking orexin potentially can have a positive effect not only on people with the disorders of sleep, but also on the patients, who suffer from various forms of dependences. However, to become acquainted with the results of investigating Francois zhenk is possible in the last release of periodical Nature Medicine. But with the "alcoholic" action of neurohormone - also into Nature, only in July 2006. Valium without prescription
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